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If the cumulative frequency (total number of animals responding at a given dose) is plotted against the logarithm of the dose (abscissa), a sigmoidal curve results (C, graph at left, semilogarithmic scale). The inflection point of the curve lies at the dose at which one-half of the group has responded.
Plasminogen activators can be infused for the purpose of dissolving clots (e. g. , in myocardial infarction). Thrombolysis is not likely to be successful unless the activators can be given very soon after thrombus formation. Urokinase is an endogenous plasminogen activator obtained from cultured human kidney cells. Urokinase is better tolerated than is streptokinase. |
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