Drug Name: Imitrex (Sumatriptan)

If the cumulative frequency (total number of animals responding at a given dose) is plotted against the logarithm of the dose (abscissa), a sigmoidal curve results (C, graph at left, semilogarithmic scale). The inflection point of the curve lies at the dose at which one-half of the group has responded.
The same considerations hold for acidic molecules, with the important difference that alkalinization of the urine (increased pH) will promote the deprotonization of -COOH groups and thus impede reabsorption. Intentional alteration in urinary pH can be used in intoxications with proton-acceptor substances in order to hasten elimination of the toxin.

 

Plasminogen activators can be infused for the purpose of dissolving clots (e. g. , in myocardial infarction). Thrombolysis is not likely to be successful unless the activators can be given very soon after thrombus formation. Urokinase is an endogenous plasminogen activator obtained from cultured human kidney cells. Urokinase is better tolerated than is streptokinase.
Amiodarone is reserved for special cases. Anemia denotes a reduction in red blood cell count, hemoglobin content, or both. Oxygen (O2) transport capacity is decreased. Erythropoiesis (A). Blood corpuscles develop from stem cells through several cell divisions. Hemoglobin is then synthesized and the cell nucleus is extruded.