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Intraocular pressure rises, which must be taken into account during eye surgery. In skeletal muscle fibers whose motor nerve has been severed, ACh receptors spread in a few days over the entire cell membrane. In this case, succinylcholine would evoke a persistent depolarization with contracture and hyperkalemia.
Direct Parasympathomimetics. The choline ester, carbachol, activates M-cholinoceptors, but is not hydrolyzed by AChE. Carbachol can thus be effectively employed for local application to the eye (glaucoma) and systemic administration (bowel atonia, bladder atonia).

 

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Risk factors are: premature menopause, physical inactivity, cigarette smoking, alcohol abuse, low body weight, and calcium-poor diet. Prophylaxis: Administration of estrogen can protect against postmenopausal loss of bone mass. Frequently, conjugated estrogens are used.

 

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