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Apropos nomenclature: antibiotics are produced by microorganisms (fungi, bacteria) and are directed “against life” at any phylogenetic level (prokaryotes, eukaryotes). Chemotherapeutic agents originate from chemical synthesis. This distinction has been lost in current usage.
The resulting striatal dopamine deficiency leads to overactivity of cholinergic interneurons and imbalance of striopallidal output pathways, manifested by poverty of movement (akinesia), muscle stiffness (rigidity), tremor at rest, postural instability, and gait disturbance. Pharmacotherapeutic measures are aimed at restoring dopaminergic function or suppressing cholinergic hyperactivity.

 

In renal arterial stenosis, the RAA system may be needed for maintaining renal function and ACE inhibitors may precipitate renal failure. Dry cough is a fairly frequent side effect, possibly caused by reduced inactivation of kinins in the bronchial mucosa. Rarely, disturbances of taste sensation, exanthema, neutropenia, proteinuria, and angioneurotic edema may occur.
They suppress activation of ?1-receptors without a concomitant enhancement of norepinephrine release. ?1-Blockers may be used in hypertension.

 

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